To access the data, click or select the words “Appendix 4.” This will initiate the download of a compressed (pdf) archive that contains the file

A: Cell-death signaling map summarizing the regulation and gene interactions of retinal-regulated genes after intraorbital nerve crush (IONC) and intraorbital nerve transection (IONT) injuries. Data from our array analyses were loaded in MetacoreTM and MapEditorTM softwares (Genego Inc.). Significantly regulated MetacoreTM cell death signaling maps were merged and a custom map was generated using curated gene interactions. Gene interactions are represented by directional color-coded arrows: gray unknown, green: activation, red: repression or inactivation of the target. Interactions are as follow: B: binding; +P: phosphorylation; TR: transcription; C: cleavage; IE: influence on expression; ?: not specified. TNFR1a, TRADD, c-fos (AP-1 complex) and Caspase 3 protein expression has been analyzed by western blotting, and Stat-1, TNFR1a, and TNFR12a mRNA regulation has been validated by qRT–PCR. B: Temporal expression of IONT- and IONC-regulated genes shown in the signaling map in A. Data shown here are significant fold changes. Values below 1 mean downregulation and above 1 upregulation compared to naïve samples.