Figure 6 of Vij, Mol Vis 2008; 14:1020-1027.


Figure 6. Schematic of PDGF-mediated corneal wound healing. PDGF secreted at the site of the corneal wound induces its receptors on the corneal fibroblast that induces JAK2 followed by STAT3 phosphorylation and nuclear translocation. STAT3 induces the transcription of genes involved in cell growth, migration, and IL8 chemokine secretion resulting in the initiation of corneal wound healing. SOCS3 serves as an endogenous regulator of JAK2-STAT3 inhibition as seen with the chemical inhibitor, AG-490, in vitro.