Figure 5. PDGF-induced cell migration
involves JAK2-STAT3 pathway. Human corneal fibroblasts were exposed to
PDGF in the presence or absence of JAK2-STAT3 inhibitor, AG-490, for 8
h, and cell migration was quantified using the Boyden chamber
chemotaxis assay. PDGF-induced corneal fibroblast migration was
inhibited significatly by AG-490. The asterisk indicates a p<0.001
versus control and the double asterisk indicates a p<0.01 versus
PDGF.