Figure 3. PDGF induces IL8 chemokine
secretion via JAK2-STAT3 pathway. Human corneal fibroblast cultures
were serum-starved for 24 h and stimulated with PDGF in the presence or
absence of JAK2-STAT3 inhibitor, AG-490, for 8 h, and IL8 chemokine
levels in supernatants were measured by solid-phase sandwich ELISA.
PDGF induced IL8 chemokine secretion (twofold), and AG-490
significantly inhibits IL8 secretion. Data are shown as pg/ml
concentration. The asterisk indicates a p<0.01 versus control.