Figure 3 of Vij, Mol Vis 2008; 14:1020-1027.


Figure 3. PDGF induces IL8 chemokine secretion via JAK2-STAT3 pathway. Human corneal fibroblast cultures were serum-starved for 24 h and stimulated with PDGF in the presence or absence of JAK2-STAT3 inhibitor, AG-490, for 8 h, and IL8 chemokine levels in supernatants were measured by solid-phase sandwich ELISA. PDGF induced IL8 chemokine secretion (twofold), and AG-490 significantly inhibits IL8 secretion. Data are shown as pg/ml concentration. The asterisk indicates a p<0.01 versus control.