Figure 2. TGZ attenuates TGF-β2-induced collagen type I production in ARPE-19 cells. ARPE-19 cells were either left untreated or were treated with 4 ng/ml TGFβ2 for 48 h, or were pretreated with TGZ (1, 5, 10 μM), 10 μM SB203580, or DMSO for 1 h and then exposed to TGFβ2 for additional 48 h. The concentration of PICP (C-terminal propeptide of collagen type I) in the culture media under the various treatment conditions was measured by ELISA. Data represent the mean ± SD of results in four independent experiments. *p<0.01, compared with TGFβ2-treated cells. ^#p<0.05, versus SB203580-pretreated cells.