Table 3 of Dejneka, Mol Vis 2008; 14:997-1005.

Table 3. Disposition kinetics of the total radioactivity in ocular tissues of Dutch-Belted rabbits following a single intravitreal bolus injection of 3H-bevasiranib.




tmax Cmax tlast AUC0-tlast AUC0-inf. %Extrapolation kel t1/2el
Group Sex Sample (h) (μg eq/g) (h) (μg eq·h/g) (μg eq·h/g) AUC0-inf. (h-1) (h)
1 Males Aqueous Fluid 24 20.1 168 1654 a A a a
1 Males Eye (Right) 6 205 168 11936 13402 10.9 0.01 55.7
1 Males Iris 72 50.1 168 5814 a A a a
1 Males Retina 72 370 168 47235 a A a a
1 Males Sclera (+ choroid) 24 88.7 168 8916 a A a a
1 Males Vitreous fluid 0 499 168 24725 25176 1.8 0.02 30
1 Females Aqueous Fluid 24 28.9 168 1812 a A a a
1 Females Eye (Right) 6 175 168 12737 14281 10.8 0.01 50.7
1 Females Iris 24 37.3 168 5282 a A a a
1 Females Retina 72 343 168 45527 a A a a
1 Females Sclera (+ choroid) 24 75.6 168 8280 a A a a
1 Females Vitreous fluid 0 372 168 24301 24840 2.2 0.02 30.7
2 Males Aqueous Fluid 24 125 168 12589 a A a a
2 Males Eye (Right) 6 781 168 71089 85914 17.3 0.01 69
2 Males Iris 72 189 168 25065 a A a a
2 Males Retina 168 683 168 98185 a A a a
2 Males Sclera (+ choroid) 6 341 168 34724 a A a a
2 Males Vitreous fluid 0 2154 168 139913 154893 9.7 0.01 51.7
2 Females Aqueous Fluid 24 127 168 10334 a A a a
2 Females Eye (Right) 6 818 168 67323 85177 21 0.01 77.7
2 Females Iris 24 149 168 18915 a A a a
2 Females Retina 168 628 168 82229 a A a a
2 Females Sclera (+ choroid) 6 381 168 29642 a A a a
2 Females Vitreous fluid 0 1896 168 117832 134198 12.2 0.01 55.1

aIt was not possible to estimate the kel with an acceptable degree of confidence due to an inability to characterize the terminal phase. Consequently, all parameters derived from this, t1/2, AUC0-inf. and % extrapolation AUC0-inf. were not estimated.

Dejneka, Mol Vis 2008; 14:997-1005. http://www.molvis.org/molvis/v14/a119

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