Table 3 of Dejneka, Mol Vis 2008; 14:997-1005.
Table 3. Disposition kinetics of the total radioactivity in ocular tissues of Dutch-Belted rabbits following a single intravitreal bolus injection of 3H-bevasiranib.
tmax | Cmax | tlast | AUC0-tlast | AUC0-inf. | %Extrapolation | kel | t1/2el | |||
Group | Sex | Sample | (h) | (μg eq/g) | (h) | (μg eq·h/g) | (μg eq·h/g) | AUC0-inf. | (h-1) | (h) |
1 | Males | Aqueous Fluid | 24 | 20.1 | 168 | 1654 | a | A | a | a |
1 | Males | Eye (Right) | 6 | 205 | 168 | 11936 | 13402 | 10.9 | 0.01 | 55.7 |
1 | Males | Iris | 72 | 50.1 | 168 | 5814 | a | A | a | a |
1 | Males | Retina | 72 | 370 | 168 | 47235 | a | A | a | a |
1 | Males | Sclera (+ choroid) | 24 | 88.7 | 168 | 8916 | a | A | a | a |
1 | Males | Vitreous fluid | 0 | 499 | 168 | 24725 | 25176 | 1.8 | 0.02 | 30 |
1 | Females | Aqueous Fluid | 24 | 28.9 | 168 | 1812 | a | A | a | a |
1 | Females | Eye (Right) | 6 | 175 | 168 | 12737 | 14281 | 10.8 | 0.01 | 50.7 |
1 | Females | Iris | 24 | 37.3 | 168 | 5282 | a | A | a | a |
1 | Females | Retina | 72 | 343 | 168 | 45527 | a | A | a | a |
1 | Females | Sclera (+ choroid) | 24 | 75.6 | 168 | 8280 | a | A | a | a |
1 | Females | Vitreous fluid | 0 | 372 | 168 | 24301 | 24840 | 2.2 | 0.02 | 30.7 |
2 | Males | Aqueous Fluid | 24 | 125 | 168 | 12589 | a | A | a | a |
2 | Males | Eye (Right) | 6 | 781 | 168 | 71089 | 85914 | 17.3 | 0.01 | 69 |
2 | Males | Iris | 72 | 189 | 168 | 25065 | a | A | a | a |
2 | Males | Retina | 168 | 683 | 168 | 98185 | a | A | a | a |
2 | Males | Sclera (+ choroid) | 6 | 341 | 168 | 34724 | a | A | a | a |
2 | Males | Vitreous fluid | 0 | 2154 | 168 | 139913 | 154893 | 9.7 | 0.01 | 51.7 |
2 | Females | Aqueous Fluid | 24 | 127 | 168 | 10334 | a | A | a | a |
2 | Females | Eye (Right) | 6 | 818 | 168 | 67323 | 85177 | 21 | 0.01 | 77.7 |
2 | Females | Iris | 24 | 149 | 168 | 18915 | a | A | a | a |
2 | Females | Retina | 168 | 628 | 168 | 82229 | a | A | a | a |
2 | Females | Sclera (+ choroid) | 6 | 381 | 168 | 29642 | a | A | a | a |
2 | Females | Vitreous fluid | 0 | 1896 | 168 | 117832 | 134198 | 12.2 | 0.01 | 55.1 |