Molecular Vision: Dejneka, Mol Vis 2008; 14:997-1005. Table 2

Table 2. Mean radioactivity content in tissue of Dutch-Belted rabbits following a single intravitreal bolus of ³H-bevasiranib.

			Percent of dose^a
Group	Sex	Sample	6 h	24 h	72 h	168 h
1	Males	Aqueous fluid	0.5	0.4	0.5	0.05
1	Males	Eye (right)	92.1	46.5	36.9	8.8
1	Males	Iris	0.1	0.2	0.3	0.1
1	Males	Retina	0.5	0.9	2	2.3
1	Males	Sclera (+ choroid)	4.4	6	3.8	1.7
1	Males	Vitreous fluid	83.1	41.2	20	1.7
1	Females	Aqueous fluid	0.2	1.4	0.5	0.1
1	Females	Eye (right)	85.7	76.1	29.6	10
1	Females	Iris	0.04	0.2	0.2	0.2
1	Females	Retina	0.5	1.2	2.3	2.8
1	Females	Sclera (+ choroid)	4.5	4.8	4	1.3
1	Females	Vitreous fluid	82.6	57.1	18.6	2
2	Males	Aqueous fluid	0.9	1.2	0.9	0.2
2	Males	Eye (right)	91.9	73.2	51.7	15.8
2	Males	Iris	0.1	0.2	0.3	0.2
2	Males	Retina	0.3	0.8	0.9	1.4
2	Males	Sclera (+ choroid)	7.5	6.4	3.4	1.3
2	Males	Vitreous fluid	65.1	54	37.5	8.1
2	Females	Aqueous fluid	1.2	1.1	0.4	0.2
2	Females	Eye (right)	90.5	60.1	47.7	17.5
2	Females	Iris	0.2	0.2	0.1	0.2
2	Females	Retina	0.5	0.7	0.9	1.5
2	Females	Sclera (+ choroid)	6.6	5.4	1.7	1.1
2	Females	Vitreous fluid	63.2	50.1	25.1	10.3

Male (n=8) and female (n=8) rabbits were treated with ³H-bevasiranib via intravitreal injection. Group 1 animals received 0.5 mg bevasiranib/eye. Group 2 animals received 2.0 mg/bevasiranib/eye. Two animals of each sex (total 4 rabbits) were sacrificed at predetermined times (6, 24, 72, and 168 h) post-injection. Whole eyes (right eyes) and dissected ocular tissues from left eyes were analyzed for levels of radioactivity. The mean percentage of radioactivity found in each ocular structure is reported. ^aMean, n=2.