Figure 2. Linkage disequilibrium (LD) pattern (r²) of the five coding single nucleotide polymorphisms in CYP1B1 in primary open-angle glaucoma patients and controls. The extent of LD lowers as the shading gets lighter (calculated with Haploview 3.2 using standard color schemes). It is to be noted that the direction (5′ to 3′) of the cSNPs in the top panel (cartoon of the gene) and the bottom panel (LD pattern) is reversed.