Figure 4. No retinal pigment epithelium translocation in the absence of photoreceptors

Eyes were obtained from the S334ter transgenic rats 15 days (A) or 45 days (B) after Matrigel injection. No photoreceptors or outer nuclear layer were identifiable. The Matrigel layer (M) was between the retinal pigment epithelium (RPE) and the rest of the neuronal retina. RPE cells attached to Bruch's membrane. No obvious RPE migration is detected. No new RPE layer formed on the retinal side of the Matrigel layer. Significant hyperpigmentation occurred in the RPE (B). INL indicates inner nuclear layer. The scale bar represents 20 μm.