Table 8 of
Lopez-Martinez, Mol Vis 2007;
13:862-872.Table 8 of
Lopez-Martinez, Mol Vis 2007;
13:862-872.
Table 8. Clinical features of glaucoma patients with pathogenic myocilin mutations
Mutation information was based on the MYOC GenBank accession number: NM_000261. IOP values were obtained following medical treatment. IOP records before treatment were not always available. The asterisk indicates novel mutations. IOP: intraocular pressure, OD: right eye, OS: left eye, C/D: cup-disc ratio of optic nerve, ND: not determined due to oblique insertion of the optic nerve head.
Visual Treatment
Age at the IOP C/D field (number of
Subject time of Age at OD/OS Ratio alteration Iridocorneal drugs)/
Mutation number the study diagnosis Gender (mmHg) (OD/OS) (OD/OS) angle surgery
------------ ------- ---------- --------- ------ ------- ------- ---------- ------------ ----------
R346T* 19 66 44 M 10/10 0.9/0.7 Severe/ 1/2 3/Yes
(c.1059 G>C) severe
Q368Stop 67 68 56 M 20/16 0.9/0.9 Severe/ 4 2/Yes
(c.1124C>T) severe
A445V 50 72 67 F 15/15 ND/ND Early/ 4 2/No
(c.1356 C>T) early
Y479H* 3 40 32 M 14/16 0.4/0.4 Early/ 4 1/No
(c.1457 T>C) early
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