Figure 3. Multiple amino acid sequence alignment of myocilin from different species

Sequence alignment was generated by ClustalW. Residues affected by mutations are indicated by arrowheads. Asterisks indicate amino acid positions at which all query sequences are identical. Amino acid positions at which all analyzed sequences have amino acids that are chemically similar are denoted by two dots (:). One dot denotes amino acid positions with weak chemical similarity (.). Arrows indicated regions of the polypeptide chain which are predicted to fold into a beta-sheet conformation.