Figure 3. Avascular retinal area and clock hours of intravitreous neovascularization and capillary densities of n-acetylcysteine treated pups

A: Avascular retinal areas from pups exposed to 50/10 oxygen-induced retinopathy (OIR) that had intraperitoneal (IP) injections of n-acetylcysteine (NAC) (n=6 each) at p2, p6, and p10 (early treatment group) or once every 24 h from p12-p17 (n=6 each; late treatment group) and assayed at p18 showed no significant difference compared to respective PBS controls (n=6 each; early, p=0.54; late, p=0.19; Student t-test). B: Clock hours of intravitreous neovascularization (IVNV) in retinas of OIR pups after IP injections of NAC (n=6 each) at p2, p6, and p10 (early treatment group) or once every 24 h from p12-p17 (n=6 each; late treatment group) and assayed at p18 showed no significant difference compared to respective PBS controls (n=6 each; early, p=0.56; late, p=0.51; Mann-Whitney test). C: Capillary densities did not differ between NAC- or PBS- injected early treatment groups (p=0.88; n=6, Student t-test).