Table 3 of Seigel, Mol Vis 2007; 13:823-832.


Table 3. Human embryonic genes upregulated in human retinoblastoma tumors and expressed in Y79 cells

Microarray analysis was used to compare human retinoblastoma (RB) tumors (n=3) with normal retinal tissue (n=3) Human embryonic genes of interest that were upregulated as compared with normal retina were cross-referenced with independently-derived microarray data from Y79 retinoblastoma cells. The genes listed in this table represent human embryonic stem cell genes that are upregulated in RB (as compared with normal retina) and are also present in Y79 cells.

                                      Avg.
                                   fold-change   Avg. FDR
     Gene              Gene ID        Log2        value
------------------   -----------   -----------   --------
Oct 3/4              NM_002701.3          1.19       0.61
Nanog                NM_024865            1.24      0.518
Musashi-1            NM_002442            1.14      0.765
Musashi-2            NM_138962.2         1.028      0.513
MCM2                 NM_004526.2          3.56      0.777
Meis-1               NM_002398.2          1.37      0.606
Nestin               NM_006617.1          0.68      0.172
Reelin               NM_005045.2          1.12      0.766
Jagged-2             NM_145159.1          1.68      0.764
NCAM-1               NM_181351.1          1.37      0.636
Prominin-1 (CD133)   NM_006017.1           1.4      0.583
Thy-1                NM_006288.2           1.2      0.479
Patched              NM_000264            1.14      0.659
Notch-4              NM_004557.3          1.12      0.454

Seigel, Mol Vis 2007; 13:823-832 <http://www.molvis.org/molvis/v13/a90/>
©2007 Molecular Vision <http://www.molvis.org/molvis/>
ISSN 1090-0535