Table 3 of
Danciger, Mol Vis 2007;
13:79-85.Table 3 of
Danciger, Mol Vis 2007;
13:79-85.
Table 3. Quantitative trait loci from the age-related retinal degeneration A x B intercross study
Analysis with Map Manager QTXb20. Quantitative trait based on the mean of all outer nuclear layer (ONL) thickness measurements. 1HS represents highly significant; S represents significant; Sugg represents suggestive, 2cM positions are the distances from the centromere taken from the MGI map, 3Mb positions were determined from MGI based on the UniSTS annotation of NCBI Build 36.1 and rounded to the nearest 0.1 million bases. Distances shown are from the acrocentric centromere, 4The percent total genetic effect represents percentage effect for this locus divided by total percentage effect of controls (89%) rounded to the nearest whole number, 5the 59 controls include 14 A/J, 14 C57BL/6J, and 31 F1 mice, 6when two models are noted, both have similar percentage effects and similar LOD scores, 7The negative or "-" percentage genetic effect score indicates a B-susceptible allele; all other percentage genetic effect scores indicate B-protective alleles.
Marker(s) at cM2 from Mb3 from LOD % effect (%total Best fitting
Sig1 peak of QTL centromere centromere score genetic effect)4 inheritance model
---- ------------ ---------- ---------- ----- ---------------- -----------------
HS 595 controls --- --- 27.76 89 (100) dominant
Sugg D12Mit16 53.0 105.3
D12NDS2 59.0 --- 2.91 8 (9) recessive
Sugg D13Mit13 35.0 55.1
D13Mit256 40.0 --- 2.85 7 (8) add/dom6
Sugg D17Mit51 22.9 41.0
D17Mit20 34.3 54.9 2.22 5 (6) dominant
Sugg D14Mit98 3.0 15.0
D14Mit60 15.0 46.0 2.15 5 (6) additive
Sugg D12Mit59 13.0 28.1
D12Mit91 29.0 68.6 2.24 -5 (-6)7 recessive
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