Figure 3 of Guleria, Mol Vis 2007; 13:797-803.

Figure 3. Schematic diagram of the connexin 46 polypeptide and locations of identified mutations

Connexin 46 polypeptide (435 amino acids) has nine structural domains including a cytoplasmic NH2-terminus, four transmembrane domains (M1-M4), two extracellular loops (E1-E2), a cytoplasmic loop, and a cytoplasmic COOH-terminus (modified figure from Bennett et al. [31]). The relative location of the T87M mutation (indicated in red) and other reported mutations associated with congenital cataracts in humans are marked.

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Guleria, Mol Vis 2007; 13:797-803 <>
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