Table 2 of
Szabo, Mol Vis 2007;
13:659-666.Table 2 of
Szabo, Mol Vis 2007;
13:659-666.
Table 2. Maximal IOP values in patients carrying various alleles of N363S, Bcl I, and ER22/23EK polymorphisms.
Patients carrying the G allele of the N363S polymorphism had significantly higher maximal IOP during the prednisolone acetate treatment (marked with asterisks, p=0.03). Other factors, like frequency of Bcl I and ER22/23EK polymorphisms, photoablation depth, and initial IOP, were statistically significant neither in analysis groups A1 and A2 nor in analysis group B. Abbreviations: SNP: Single nucleotide polymorphism, WT: wild type, P: polymorphic genotype, n: number of eyes studied.
Maximal IOP during steroid therapy (mmHg, mean±SD)
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SNP Genotype Analysis A1 Analysis A2 Analysis B
--------- -------- ---------------- --------------- ----------------
N363S WT:AA 18.2±4.3 (n=124) 24.4±8.1 (n=37) 23.4±7.9 (n=70)*
P:AG 16.0±1.2 (n=8) 27.7±6.2 (n=5) 31.0±7.8 (n=6)*
Bcl I WT:GG 18.4±4.3 (n=64) 26.7±8.4 (n=23) 25.0±8.9 (n=26)
P:GC,CC 17.7±4.1 (n=68) 22.5±6.8 (n=19) 23.4±7.3 (n=40)
ER22/23EK WT:GG 18.0±4.3 (n=131) 24.5±8.0 (n=39) 24.0±8.2 (n=72)
P:GC,CC 19.0 (n=1) 27.8±6.0 (n=3) 26.3±4.9 (n=4)
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