Table 3. Two-way analyses of complement factor H 402 and rs11200638

Four genotypic models for rs11200638 are considered: Let r0, r1, and r2 be the marginal relative risks for genotypes GG, GA, and AA. Then, recessive model implies r0=r1; multiplicative model implies r1=r0r2; dominant model implies r2=r1; full model does not have any restriction on relative risks except that r0, r1, r2>0. The 95% confidence intervals (CI) of population attributable risk (PAR) were obtained via a bootstrap re-sampling method with 999 replicates. Mantel-Hanzel (M-H) tests are conducted for one SNP association adjusted for the other SNP; likelihood ratio tests (LRT) for joint single nucleotide polymorphism (SNP) association under a two-way multiplicative model: the relative risk (or OR) for any genotype pair (A, B) relative to the baseline pair (A0, B0) is the product of relative risk (or OR) of A relative to A0 and that of B relative to B0. AIC denotes the Akaike's information criterion to access goodness-of-fit for the rs11200638 model.

                                                                  M-H test: p-value
                           PAR%                 (95% CI)          -----------------
Model for        ------------------------   --------------------     LRT       AIC
rs11200638       CFH 402      rs11200638    CFH 402   rs11200638   p-value   value
--------------   ---------   ------------   -------   ----------   -------   -----
Full             3.4         58.3           0.07      8.30E-08     0.03      221.8
                 (0, 9.7)    (50.5, 64.1)
Recessive        4.6         44             0.23      6.20E-09     0.12      221.5
                 (0, 10.7)   (40.5, 54.0)
Multiplicative   1.7         79.8           *         *            0.02      225.7
                 (0, 7.8)    (73.0, 88.1)
Dominant         2.2         58.6           0.91      5.80E-04     0.1       246.9
                 (0, 13.7)   (43.9, 78.9)