Table 3 of
Tang, Mol Vis 2007;
13:534-544.Table 3 of
Tang, Mol Vis 2007;
13:534-544.
Table 3. MYOC polymorphisms: summary of genetics data for parents and tests of association by family-based association testing under different genetic models in 162 nuclear families
The polymorphisms are shown in order from the 5' end to the 3' end of the MYOC gene: the first four markers in the top part and the last three markers in the bottom part (See Figure 1 for details). For single nucleotide polymorphisms, the major allele was designated as 1 and minor allele as 2, with the identities of the alleles shown within brackets. For microsatellites, four alleles were found for NGA17 and six alleles for NGA19, with the number of GT repeats shown within brackets. "No. of families" refers to the number of informative families in which there was at least one heterozygous parent while "-" indicates that the corresponding value was not calculated because the number of informative families was less than 10. The degree of freedom (n) is shown within brackets after chi2: χ2(n), where n=1, 2, or 3.
Marker rs2075537 NGA17 rs235920 rs7523603
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Allele 1 (G) 2 (T) 3 (13) 4 (14) 5 (15) 6 (16) 1 (T) 2 (C) 1 (A) 2 (G)
Freq in parents 0.5633 0.4367 0.5015 0.1836 0.3117 0.0031 0.5355 0.4645 0.7562 0.2438
FBAT - Additive model
No. of families 125 125 123 74 107 2 121 121 91 91
Z score -0.45 0.45 1.34 1.56 -2.59 - -1.09 1.09 1.21 -1.21
p value 0.6526 0.6526 0.1797 0.12 0.0097 - 0.2774 0.2774 0.2283 0.2283
Global stat. chi2(1)=0.203 chi2(3)=11.733 chi2(1)=1.180 chi2(1)=1.452
p=0.6526 p=0.0084 p=0.2774 p=0.2283
FBAT - Dominant model
No. of families 70 95 82 73 94 2 79 88 32 78
Z score -0.21 0.45 0.87 1.46 -2.47 - -0.97 0.70 1.65 -0.52
p value 0.8316 0.6528 0.3843 0.1455 0.01443 - 0.3316 0.4838 0.09945 0.6004
Global stat. chi2(2)=0.225 chi2(3)=7.366 chi2(2)=1.243 chi2(2)=2.850
p=0.8934 p=0.0611 p=0.5372 p=0.2405
FBAT - Recessive model
No. of families 95 70 83 18 38 0 88 79 78 32
Z score -0.45 0.21 1.17 0.76 -1.19 - -0.70 0.97 0.52 -1.65
p value 0.6528 0.8316 0.2438 0.4477 0.233 - 0.4838 0.3316 0.6004 0.0995
Global stat. chi2(2)=0.225 chi2(3)=3.212 chi2(2)=1.243 chi2(2)=2.850
p=0.8934 p=0.3601 p=0.5372 p=0.2405
Marker NGA19 rs2421853 rs235858
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Allele 1 (11) 3 (13) 4 (14) 5 (15) 6 (16) 7 (17) 1 (C) 2 (T) 1 (T) 2 (C)
Freq in parents 0.0015 0.2176 0.0077 0.7114 0.0602 0.0015 0.7299 0.2701 0.6003 0.3997
FBAT - Additive model
No. of families 1 96 5 115 32 1 102 102 109 109
Z score - -3.03 - 2.1 1.13 - -3.32 3.32 4.60 -4.60
p value - 0.0024 - 0.0353 0.2579 - 0.0009 0.0009 4.0E-06 4.0E-06
Global stat. chi2(3)=10.162 chi2(1)=11.000 chi2(1)=21.146
p=0.0172 p=0.0009 p=4.0E-6
FBAT - Dominant model
--------------- ----------------------------------------------- -------------- --------------
No. of families 1 91 5 42 32 1 26 95 54 87
Z score - -2.28 - 2.83 0.93 - -1.80 2.97 2.92 -3.90
p value - 0.0224 - 0.0047 0.3519 - 0.0725 0.0030 0.0035 9.6E-05
Global stat. chi2(3)=12.711 chi2(2)=11.011 chi2(2)=21.165
p=0.0053 p=0.0041 p=2.5E-5
FBAT - Recessive model
--------------- ----------------------------------------------- -------------- --------------
No. of families 0 28 0 107 1 0 95 26 87 54
Z score - -2.53 - 0.92 - - -2.97 1.80 3.90 -2.92
p value - 0.0113 - 0.3576 - - 0.0030 0.0725 9.6E-05 0.0035
Global stat. chi2(2)=6.837 chi2(2)=11.011 chi2(2)=21.165
p=0.0328 p=0.0041 p=2.5E-5
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