Figure 7. Amino acid sequence alignment of the human PAX6 paired domain

A shows alignment of human PAX6 protein sequence with seven other species: Takifugu rubripes, Lineus sanguineus, Rattus norvegicus, Mus musculus, Drosophila melanogaster, Gallus gallus, and Danio rerio. The PAX6 PD is highly conserved throughout species. The amino acids affected by mutation in the PD reported in this study are shown in color. B shows the PD amino acid sequence alignment of all PAX genes (PAX1-5 and PAX7-9). The amino acids affected by mutation in the PD reported in this study are shown in color. The PD is highly conserved troughout all PAX proteins.