Figure 2. Haplotype analysis of family 2

Haplotype analysis was carried out using 11 microsatellite markers. Disease haplotype is boxed. Note the affected individuals (viz., III-1, III-3, III-5, IV-3, and IV-6) are homozygous for the disease haplotype. Whereas individuals II-3, IV-1, IV-5, IV-7, IV-8, V-3, and V-4 are heterozygous for the disease haplotype and are therefore carriers for the mutation. Empty squares and circles represent normal males and females, respectively. Filled squares and circles represent affected individuals. Affected individuals III-1, III-3, III-5, IV-3, and IV-6 are 70, 65, 45, 30, and 30 years old, respectively.