Figure 7. Regulation of L-type channels

A: Intracellular application of pp60^c-src (30 U/ml) via the patch pipette in cultured cells from eyes without choroidal neovascularization (CNV): change in maximal currents amplitudes by active pp60^c-src versus heat-inactivated pp60^c-src. B: Intracellular application of pp60^c-src via the patch pipette in cultured cells from CNV membranes: change in the maximal current amplitudes by active pp60^c-src versus heat-inactivated pp60^c-src. C: Effect of the src-kinase inhibitors herbimycin A (10^-5 M) and SU6656 (10^-6 M) on current density in cultured cells from eyes without CNV and from CNV membranes. D: Effect of basic fibroblast growth factor (bFGF) application (10 ng/ml) on L-type currents in cultured cells from eye without CNV and from CNV membranes. Control represents current amplitude before bFGF application, bFGF represents current amplitude after bFGF application.