Figure 6. Vascular endothelial growth factor secretion

A: Increase of vascular endothelial growth factor (VEGF) concentration in the test solution over time (each group: n=3 which represent 3 cultures from 3 different patients). B: Effect of L-type Ca²⁺ channel modulation (inhibition: nifedipine, (+)BayK8644 enantiomer; activation: (-)BayK8644 enantiomer) on VEGF secretion by cells from eyes without CNV (8 h values). C: Effect of L-type channel modulation (inhibition: nifedipine, 10^-5 (+)BayK8644 enantiomer; activation: 10^-5 (-)BayK 8644 enantiomer) on VEGF secretion rate in cells from choroidal neovascularization (CNV) membranes (8 h values). D: Effect of nifedipine on basic fibroblast growth factor (bFGF) induced rise in the VEGF secretion rate by cells from eyes without CNV (left bars) and from CNV membranes (right bars; 8 h values).