Figure 3. Lens histology in wild type (WT) and transgenic lines OVE442, LR12, and LR22 at birth

Fiber cell elongation was defective in all transgenic families, resulting in the presence of a subepithelial lumen (marked with asterisks). In the mildly affected line LR12, the lens polarity and the transitional zone (t) look normal. In the two severely affected lines (OVE442 and LR22), the transitional zone (t) is shifted anteriorly and is dramatically expanded (as shown in brackets).