Table 6 of
Ahad, Mol Vis 2007;
13:388-396.Table 6 of
Ahad, Mol Vis 2007;
13:388-396.
Table 6. Summary of significant associations between the chemokine polymorphisms and idiopathic posterior segment uveitis
This table shows the effect of chemokine SNPs on the phenotype of idiopathic posterior segment uveitis. Logistic regression model was used to perform the statistical calculations. Results show that chemokine SNPs can affect the phenotype of idiopathic posterior segment uveitis and can be predictors of severity and complications. Asterisk indicates idiopathic posterior segment uveitis.
Phenotype Genotype p value
------------------- -------------------------------------- -------
MCP-1 -2518 AA MCP-1 -2518 AG & GG
n=82 n=59
Mean age of onset 41 years 33 years pc=0.003
of *IPSU
RANTES -403GG RANTES -403 GA & AA
n=86 n=55
Severe inflammatory 38% (33) 20% (11) pc=0.04
episodes
CCR5 wt/wt CCR5 del/wt & del/del
n=109 n=32
Meanv Visual acuity 6/9 6/6 pc=0.028
after 18 months
CCR2 VV CCR2 VI & II
n=116 n=25
Meanv Visual acuity 6/9 6/15 pc=0.04
after 18 months
Raised intra-ocular 27% (31) 60% (15) pc=0.007
pressure
CCR5 -59029 GG CCR5 -59029 GA & AA
n=30 n=111
On long term 20% (6) 40% (44) pc=0.051
corticosteroid
treatment
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