Table 4 of
Ahad, Mol Vis 2007;
13:388-396.Table 4 of
Ahad, Mol Vis 2007;
13:388-396.
Table 4. Allelic frequencies of chemokine single nucleotide polymorphisms in major subgroups of idiopathic posterior segment uveitis
Idiopathic posterior segment uveitis was divided into four types on the basis of site of inflammation. Subgroup analysis did not reveal any association of chemokine SNPs with any phenotype of uveitis apart from CCR2 64I allele, which was slightly higher in patients with intermediate uveitis (12%) when compared to the controls (7%; p=0.03, pc=0.09). The genotypic frequencies are shown in percentages.
Intermediate Pan Posterior Grand
uveitis uveitis uveitis Vasculitis total
Genotype n=(77) n=(17) n=(29) n=(18) n=(141)
--------------------------- ------------ ------- --------- ---------- -------
MCP-1 -2518 A/G AA 53% 71% 69% 50% 58%
AG 43% 18% 28% 44% 37%
GG 4% 12% 3% 6% 5%
RANTES -403 G/A GG 58% 71% 59% 67% 61%
GA 40% 24% 31% 28% 35%
AA 1% 6% 10% 6% 4%
RANTES -28 C/G CC 95% 88% 93% 100% 94%
CG 5% 12% 7% 0% 6%
CCR2 V64I VV 79% 76% 93% 83% 82%
VI 18% 24% 7% 17% 16%
II 3% 0% 0% 0% 1%
CCR5 -59029 G/A GG 25% 6% 17% 28% 21%
GA 40% 47% 66% 28% 45%
AA 35% 47% 17% 44% 34%
CCR5 32 bp deletion wt/wt 81% 76% 72% 72% 77%
wt/del 17% 18% 28% 28% 21%
del/del 3% 6% 0% 0% 2%
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