Figure 1. Pedigrees, haplotyes, and sequencing results of the two families with high myopia and NYX mutations

Filled squares represent individuals affected with high myopia. Haplotype analysis in Family A demonstrated that the c.144C>G mutation in III:1 is a de novo mutation. +: Mutation detected in II:1 of family B. Mut-F or Mut-R: Forward or Reverse sequencing of NYX gene fragments for individual III:1 in family A (left column) and individual II:1 in family B (right column). Wild: Forward sequencing of the corresponding fragments in normal control.