Figure 1. Melanolipofuscin accumulation

A: Comparison of Melanolipofuscin (MLF) granules from retinal pigment epithelium (RPE) of young (21.2±5.9 yrs) and old (66.5±5.9 yrs) human donors. B: Age of RPE donor versus optical density of MLF/LF plotted to show the accumulation of MLF throughout life. Lipofuscin (LF) granules are observed in human RPE from young individuals, whereas significant quantities of MLF do not appear to accumulate for decades afterward.