Figure 1 of
Zhang, Mol Vis 2007;
13:2289-2300.Figure 1 of
Zhang, Mol Vis 2007;
13:2289-2300.
Figure 1. Schematic representation of the Tox176 transgene
A: The Tox176 cDNA (700 bp) was inserted into the EcoRI and SmaI restriction sites of the DREAM vector between the minx intron and the 3' untranslated region from the αB-crystallin gene (αB pA). The injection fragment was generated by KpnI and NotI digestion. Abbreviations; δen, chicken δ-crystallin enhancer; αA, mouse αA-crystallin promoter (1.4 kb). B: DREAM-Tox176 induces microphthalmia. Eyes of a nontransgenic (NT) mouse and DREAM-Tox176 (1757) at P14 are shown. Scale bar represents 4 mm.
