Figure 1. Familial X-linked idiopathic infantile nystagmus (IIN)

A: Pedigree and haplotype analysis of family W showing segregation of 7 STR and 1 SNP marker on Xq, listed in descending order from the centromere. Individuals marked with a sharp (hash mark) underwent detailed ophthalmic examination. B: Pedigree and haplotype analysis of family M showing allelic differences with family W at markers DXS1047, DXS8094, and DXS1062. C: Ideogram of chromosome-X showing the cytogenetic locations of markers defining the IIN locus in this study (red) and the NYS1 (FRMD7) locus on Xq. The ocular albinism-1 (OA1, GPR143) and NYS1 loci on Xp are also indicated.