Table 2 of
Leveziel, Mol Vis 2007;
13:2153-2159.Table 2 of
Leveziel, Mol Vis 2007;
13:2153-2159.
Table 2. Haplotype analysis of PLEKHA1, LOC387715, and HTRA1 SNPs in cases and controls
Upper panel shows frequencies of estimated common haplotypes in cases and controls. Other possible allelic combinations involved too few individuals for haplotype estimation. Lower panel presents risk of age-related macular degeneration associated with common haplotypes, estimated by odds ratio and 95% confidence intervals after age and sex adjustment for each haplotype combination. The reference haplotype corresponds to the most prevalent in controls.
Haplotype frequency
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P less than or
PLEKHA1 LOC387715 HTRA1 Cases Controls equal
------- --------- ----- ----- ---------- --------------
G G G 0.279 0.565 0.0001
A G G 0.175 0.215 χ2; 2 df=38.6
A T A 0.475 0.190
other combinations 0.071 0.030
Risk haplotypes for exudative age related macular degeneration
----------------------------------------------------------------
Confidence
Odds interval P less than or
PLEKHA1 LOC387715 HTRA1 ratio 95% equal
------- --------- ----- ----- ---------- --------------
G G G 1
A G G 0.8 (0.5-1.2) 0.30
A T A 4.0 (2.5-6.4) 0.0001
All combinations χ2; 2 0.0001
df=43.7
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