Table 1 of
Leveziel, Mol Vis 2007;
13:2153-2159.Table 1 of
Leveziel, Mol Vis 2007;
13:2153-2159.
Table 1. Logistic regression estimation of single nucleotide polymorphisms at PLEKHA1, LOC387715, and HTRA1 genetic loci: allele, genotype frequencies, and odds ratio after adjustment for age and sex
p value represents comparison or level of risk significance between age-related macular degeneration and control groups, after Bonferonni correction.
Exudative age
related macular
degeneration Controls
n=118 n=116 p value
---------- --------------- ---------- ---------
PLEKHA1 rs4146894
Allele
G 0.33 0.59 less than
A 0.67 0.41 or equal
to 0.0001
Genotype
GG 13 (11.0%) 39 (33.6%) less than
AG 51 (43.2%) 59 (50.9%) or equal
AA 54 (45.8%) 18 (15.5%) to 0.0001
Odds Ratio
GG 1
AG 2.6 (1.3-5.5) less than
or equal
to 0.04
AA 9.1 (4.0-20.9) less than
or equal
to 0.0001
LOC387715 rs10490924
Allele
G 0.45 0.78 less than
or equal
to 0.0001
T 0.55 0.22
Genotype
GG 26 (22.0%) 71 (61.2%) less than
or equal
to 0.0001
GT 55 (46.6%) 40 (34.5%)
TT 37 (31.4%) 5 (4.3%)
Odds Ratio
GG 1
GT 3.8 (2.0-7.0) less than
or equal
to 0.0001
TT 20.4 (7.2-57.8) less than
or equal
to 0.0001
HTRA1 rs11200638
Allele
G 0.49 0.78 less than
or equal
to 0.0001
A 0.51 0.22
Genotype
GG 29 (24.4%) 70 (60.4%) less than
or equal
to 0.0001
GA 57 (47.8%) 41 (35.3%)
AA 32 (27.8%) 5 (4.3%)
Odds Ratio
GG 1
GA 3.4 (1.9-6.1) less than
or equal
to 0.0001
AA 15.5 (5.5-43.9) less than
or equal
to 0.0001
|