Table 2 of
Richardson, Mol Vis 2007;
13:2148-2152.Table 2 of
Richardson, Mol Vis 2007;
13:2148-2152.
Table 2. Genotype distribution and significance of vascular endothelial growth factor tag single nucleotide polymorphisms in total age-related macular degeneration as well as stratified by disease and controls
Asterisk means number of individuals genotyped for each single nucleotide polymorphism (SNP) varied according to genotyping success rate. Overall, this rate varied from 95.5% to 96.4%, Significance (double asterisk means p) determined using the Pearson chi-square test, is the value of association between age-related macular degeneration (AMD) total cases versus controls and AMD subtypes versus controls. The following abbreviations are used: geographic atrophy (GA), number (n), and reference SNP (rs).
Control Total AMD Early AMD Neovascular GA
n=173* n=577* n=50* AMD n=342* n=101*
--------- ---------- ---------- --------- ----------- ---------
SNPs/
Genotype n (%) n (%) n (%) n (%) n (%)
--------- ---------- ---------- --------- ----------- ---------
rs833061
TT 40 (25.5) 154 (27.2) 14 (29.8) 92 (27.4) 27 (27.0)
TC 78 (49.7) 259 (45.8) 21 (44.7) 158 (47.0) 43 (43.0)
CC 39 (24.8) 153 (27.0) 12 (25.5) 86 (25.6) 30 (30.0)
P** 0.68 0.80 0.86 0.58
rs25648
CC 111 (65.7) 387 (70.2) 37 (75.6) 232 (71.6) 62 (62.6)
CT 52 (30.8) 145 (26.3) 11 (22.4) 81 (25.0) 33 (33.3)
TT 6 (3.5) 19 (3.4) 1 (2.0) 11 (3.4) 4 (4.0)
P** 0.51 0.42 0.38 0.88
rs3024997
GG 81 (47.6) 287 (51.9) 23 (47.9) 172 (52.6) 55 (55.6)
GA 72 (42.4) 198 (35.8) 19 (39.6) 109 (33.3) 37 (37.4)
AA 17 (10.0) 68 (12.3) 6 (12.5) 46 (14.1) 7 (7.0)
P** 0.28 0.86 0.11 0.41
rs2146323
CC 78 (46.2) 229 (41.7) 19 (39.6) 133 (41.0) 37 (38.9)
CA 71 (42.0) 245 (44.6) 23 (47.9) 139 (42.9) 50 (52.6)
AA 20 (11.8) 75 (13.7) 6 (12.5) 52 (16.1) 8 (8.4)
P** 0.57 0.71 0.36 0.24
rs3025030
GG 115 (71.9) 422 (75.9) 36 (75.0) 251 (75.8) 77 (78.6)
GC 42 (26.3) 127 (22.8) 12 (25.0) 75 (22.7) 20 (20.4)
CC 3 (1.8) 7 (1.3) 0 (0.0) 5 (1.5) 1 (1.0)
P** 0.54 0.62 0.64 0.68
rs3025035
CC 143 (85.1) 461 (83.5) 40 (81.6) 275 (84.6) 81 (81.0)
CT 25 (14.9) 89 (16.1) 9 (18.4) 49 (15.1) 18 (18.0)
TT 0 (0.0) 2 (0.4) 0 (0.0) 1 (0.3) 1 (1.0)
P** 0.68 0.56 0.77 0.34
rs10434
GG 47 (29.4) 177 (31.5) 13 (27.7) 110 (32.7) 32 (33.3)
GA 79 (49.4) 287 (51.1) 23 (48.9) 174 (51.8) 47 (49.0)
AA 34 (21.2) 98 (17.4) 11 (23.4) 52 (15.5) 17 (17.7)
P** 0.54 0.94 0.27 0.71
|