Figure 1. Clusterin in an early-stage retinal hemangioblastoma associated with von Hippel Lindau

Eye number 6, A-D: Lack of clusterin immunoreactivity is apparent in the tumorlet cells (asterisks), but present in vascular components and nearby relative normal retina tissue (arrows). A and C were stained with hemtoxylin and eosin. B and D were stained with avidin-biotin-peroxidase complex immunostaining. Original magnifications in A and B were x100, in C and D were x200. INL means inner nuclear layer. ONL means outer nuclear layer.