Table 3 of
Sun, Mol Vis 2007;
13:2105-2111.Table 3 of
Sun, Mol Vis 2007;
13:2105-2111.
Table 3. Distribution of the APOE allele and genotype, by presence of retinal microvascular signs, in whites and African-Americans
Double asterisk ε2 refers to carriers of ε2 allele (ε2/ε2, ε2/ε3, and ε2/ε4) while ε4 refers to carriers of ε4 allele (ε3/ε4, ε4/ε4). Asterisk denotes participants with diabetes were excluded; arterio-venous (AV) nicking is listed for both groups. Total numbers vary due to missing data for different retinal signs.
Whites African-Americans
------------------------------------------------------------------------ -------------------------------------------------------------------
Retinopathy* AV nicking Focal narrowing Retinopathy* AV nicking Focal narrowing
---------------------- ---------------------- ---------------------- ------------------- ---------------------- --------------------
No Yes No Yes No Yes No Yes No Yes No Yes
APOE N=1212 N=107 N=1553 N=124 N=1469 N=160 N=180 N=22 N=268 N=29 N=282 N=13
------- ---------- --------- ---------- --------- ---------- ---------- --------- -------- ---------- --------- --------- --------
Allele carrier**
ε2 205 (16.9) 21 (19.6) 262 (16.9) 29 (23.4) 258 (17.6) 27 (16.9) 50 (27.8) 7 (31.8) 74 (27.6) 6 (20.7) 79 (28.0) 2 (15.4)
ε3 745 (61.5) 64 (59.8) 970 (62.5) 66 (53.2) 902 (61.4) 106 (66.3) 86 (47.8) 7 (31.8) 124 (46.3) 11 (37.9) 128 (45.4) 7 (53.8)
ε4 262 (21.6) 22 (20.6) 321 (20.7) 29 (23.4) 309 (21.0) 27 (16.9) 44 (24.4) 8 (36.4) 70 (26.1) 12 (41.4) 75 (26.6) 4 (30.8)
P 0.77 0.09 0.41 0.32 0.22 0.67
Genotype
ε2/ε2 7 (0.6) 1 (0.9) 9 (0.6) 1 (0.8) 8 (0.5) 1 (0.6) 4 (2.2) 0 (--) 5 (1.9) 0 (--) 5 (1.8) 0 (--)
ε2/ε3 158 (13.0) 18 (16.8) 204 (13.1) 24 (19.4) 207 (14.1) 19 (11.9) 42 (23.3) 7 (31.8) 60 (22.4) 6 (20.7) 65 (23.0) 2 (15.4)
ε2/ε4 40 (3.3) 2 (1.9) 49 (3.2) 4 (3.2) 43 (2.9) 7 (4.4) 4 (2.2) 0 (--) 9 (3.4) 0 (--) 9 (3.2) 0 (--)
ε3/ε3 745 (61.5) 64 (59.8) 970 (62.5) 66 (53.2) 902 (61.4) 106 (66.3) 86 (47.8) 7 (31.8) 124 (46.3) 11 (37.9) 128 (45.4) 7 (53.8)
ε3/ε4 252 (20.8) 21(19.6) 312 (20.1) 26 (21.0) 298 (20.3) 25 (15.6) 38 (21.1) 5 (22.7) 63 (23.5) 9 (31.0) 66 (23.4) 3 (23.1)
ε4/ε4 10 (0.8) 1 (0.9) 9 (0.6) 3 (2.4) 11 (0.7) 2 (1.3) 6 (3.3) 3 (13.6) 7 (2.6) 3 (10.3) 9 (3.2) 1 (7.7)
P 0.71 0.06 0.38 0.24 0.29 0.78
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