Table 4 of Miyazawa, Mol Vis 2007; 13:1912-1919.


Table 4. Comparison of clinical characteristics of patients with high tension glaucoma, according to WDR36 genotype

An asterisk indicates p<0.001, independent t-test. Clinical characteristics of patients with high tension glaucoma, according to WDR36 genotype were shown. Between the subjects having homozygote not-at-risk genotype, heterozygote genotype, and the homozygote genotype, the mean deviation (MD) of the visual field was statistically different. The MDs of subjects having the homozygote genotype were worse than those of heterozygote genotype and homozygote not-at-risk genotype.

                                                    A/A          A/G            G/G
                     Phenotype variable         wild type   heterozygote   homozygote
------------   ------------------------------   ---------   ------------   -----------
p.I264V        Age at diagnosis (y)             60.1±12.2    55.2±11.0      58.0±13.5
(c.790A>G)
               Right IOP at diagnosis (mm Hg)   25.7± 8.9    27.0± 9.0      25.5± 6.6
               Left IOP at diagnosis (mm Hg)    25.8± 6.6    26.2± 9.3      25.0± 6.1
               Right visual field; mean         -7.4± 3.4    -6.3± 3.8     -17.8± 7.5*
               deviation at diagnosis (dB)
               Left visual field; mean          -7.0± 3.8    -6.4± 4.8     -20.3± 7.8*
               deviation at diagnosis (dB)

c.1965-30A>G   Age at diagnosis (y)             60.2±12.4    54.9±10.8      59.6±13.0
               Right IOP at diagnosis (mm Hg)   25.6± 8.9    27.1± 8.9      24.8± 6.2
               Left IOP at diagnosis (mm Hg)    25.7± 6.6    26.3± 9.2      24.4± 5.8
               Right visual field; mean         -7.5± 3.5    -6.2± 3.5     -17.2± 7.2*
               deviation at diagnosis (dB)
               Left visual field; mean          -7.1± 3.9    -6.3± 4.6     -19.0± 8.1*
               deviation at diagnosis (dB)

Miyazawa, Mol Vis 2007; 13:1912-1919 <http://www.molvis.org/molvis/v13/a215/>
©2007 Molecular Vision <http://www.molvis.org/molvis/>
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