Table 4 of
Redmond, Mol Vis 2007;
13:1813-1821.Table 4 of
Redmond, Mol Vis 2007;
13:1813-1821.
Table 4. Effect of variation at residue 457 and 459 on RPE65 isomerase activity of transfected 293-F cells
Interchange of isoleucine and threonine at aa457, and methionine and valine at aa459 has no differential effect on isomerase activity of RPE65. 1Production of 11-cis retinol 2Calculated as percentage of wildtype value.
Isomerase1
Name activity2 S.D. N
------------ ---------- ---- -
dWT/T457I 116.6 15.4 4
dL450M 62.7 2.6 4
dL450M/T457I 74.8 9.4 4
mWT/I457T 119.8 10.1 4
ml450M 44.8 1.8 4
ml450M/I457T 44.0 5.1 4
dWT/V459M 93.0 3.5 4
dL450M 66.5 5.7 4
dL450M/V459M 66.8 6.8 4
mWT/M459V 94.3 3.0 4
ml450M 38.3 7.2 4
ml450M/M459V 41.4 8.2 4
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