Figure 5 of Redmond, Mol Vis 2007; 13:1813-1821.

Figure 5. Effect of human mutations at aa450 and aa457 on activity and expression of RPE65

A: 11-cis retinol production in 293-F cells transfected with constructs expressing wildtype and L450R and T457N mutants of dog RPE65. L450M and T457N mutant activities are expressed as percentage of wildtype RPE65 activity (n=3). B: Immunoblot analysis of 293-F cells expressing wildtype and L450M mutants of dog and mouse RPE65 (top panel) and of CRALBP (bottom panel). WT represents wildtype.

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