Figure 1. Time course of intraocular pressure in Brown Norway rats

IOP significantly increased in eyes with episcleral vein injection of hypertonic saline on weeks 0 and 2 (B, C, D, E) compared with eyes without injection (A; p<0.001). Overall IOP exposure was not statistically, significantly different among groups that received intravitreal injection on week 1 of GDNF microspheres (B, C), blank microspheres (D), or PBS alone (E; p=0.1852). Data are expressed as the mean±SD (n=9).