Figure 2. Pedigrees of three families with Schnyder crystalline corneal dystrophy

A-C: In each pedigree, black filled symbols represent affected individuals, symbols filled with gray represent individuals of indeterminate phenotype, and the unfilled symbols represent unaffected individuals based on examination or history. Question marks indicate individuals of unknown affected status. Below the symbol for each individual in whom DNA collection and UBIAD1 screening was performed, the presence of the wild type allele (designated by the + symbol) or the mutant allele is indicated. Chromatograms demonstrating the identified mutation and the wild-type DNA sequence are shown beneath each pedigree.