Figure 2. Haplotype analysis of a portion of family CC-644 using chromosome 13 single nucleotide polymorphic markers

Eight affected (2-3, 2-10, 3-2, 3-6, 3-17, 4-1, 4-3, and 4-8) and two unaffected (3-10 and 3-16) family members were analyzed. Recombination events were observed in three affected individuals (2-3, 3-6, and 4-1) at SNP_A-1508817 as inherited from father (2-3) to his daughter (3-6) and then to his grandson (4-1) placing the disease locus between SNP_A-1516595 and SNP_A-1508817. Red bars indicate the affected haplotypes.