Table 8 of
Ayala-Lugo, Mol Vis 2007;
13:151-163.Table 8 of
Ayala-Lugo, Mol Vis 2007;
13:151-163.
Table 8. Frequency of M98K in individuals from different populations
Under the fixed effects Mantel-Haenszel model, individual study 95% confidence interval bounds around the odds ratio are given. For compatibility with much of the published literature the two-sided Fisher's exact test p values are given for each study. Although the presence of M98K mutations in OAG cases appears to be statistically significant relative to controls, Alward et al. [11] reported that when multi-testing is taken into account their result becomes nonsignificant. Information from Leung et al. [35] was omitted because it duplicated the information contained in Fan et al. [15]. Data from Toda et al. [37] were omitted because they duplicated the observations contained in Tang et al. [20]. Pigmentary and exfoliative data were omitted from the Europe (Caucasians living in Iowa and Australia) samples reported by Alward et al. [11]. Rezaie et al. [9] reported a p value=2.18-7.
Fisher's
Cases Controls Percent 95% CI bounds exact
------------ ------------ -------------- Odds ------------- test
Source M98K Total M98K Total OAG Control ratio Lower Upper p value
------------ ---- ----- ---- ----- ---- ------- ----- ----- ----- --------
China
[14] 26 118 22 150 22.0 14.7 1.64 0.88 3.08 0.148
[15] 129 400 81 281 32.3 28.8 1.18 0.84 1.64 0.355
Japan
[11] 51 247 8 89 20.6 9.0 2.63 1.20 5.80 0.014
[16] 81 411 36 218 19.7 16.5 1.24 0.81 1.91 0.389
[17] 25 154 5 100 16.2 5.0 3.68 1.36 9.97 0.009
[20] 51 313 27 196 16.3 13.8 1.22 0.74 2.02 0.527
[21] 12 83 1 58 14.5 1.7 9.63 1.22 76.31 0.149
Asia
[This study] 3 5 29 117 60.0 24.8 4.55 0.72 28.60 0.112
Europe
[This study] 13 217 8 116 6.0 6.9 0.86 0.34 2.14 0.814
[11] 46 650 10 162 7.1 6.2 1.16 0.57 2.35 1.000
[12] 22 315 3 95 7.0 3.2 2.30 0.67 7.87 0.224
[13] 2 27 3 94 7.4 3.2 2.43 0.38 15.33 0.310
[32] 9 200 10 200 4.5 5.0 0.90 0.36 2.25 1.000
[18] 11 237 5 110 4.6 4.5 1.02 0.35 3.02 1.000
[33] 11 170 1 100 6.5 1.0 6.85 0.87 53.87 0.036
[9] 23 169 9 422 13.6 2.1 7.23 3.27 15.98 0.000
[22] 7 105 7 93 6.7 7.5 0.88 0.3 2.6 1.000
Hispanic
[This study] 1 11 1 50 9.1 2.0 4.90 0.28 85.05 0.331
Africa
[This study] 18 81 20 88 22.2 22.7 0.97 0.47 2.00 1.000
India
[19] 22 200 11 200 11.0 5.5 2.12 1.00 4.51 0.068
[39] 10 220 0 100 4.5 0 inf 1.04 inf 0.034
Mixed
[38] 28 498 17 218 5.6 7.8 0.70 0.38 1.32 0.315
[36] 14 153 9 100 9.2 9.0 1.02 0.42 2.45 1.000
[23] 8 86 8 80 9.3 10.0 0.92 0.33 2.59 1.000
[24] 12 115 4 101 10.4 4.0 2.83 0.88 9.06 0.116
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