Table 6 of
Ayala-Lugo, Mol Vis 2007;
13:151-163.Table 6 of
Ayala-Lugo, Mol Vis 2007;
13:151-163.
Table 6. Comparison of R545Q frequency in different populations
The asterisks denote a calculation based on adding 0.5 to each cell in cases with a zero cell frequency, otherwise the value is nonexistent. Lower and upper bounds refer to the individual study 95% confidence interval around the odds ratio for a fixed effects Mantel-Haenszel model. Information from Leung et al. [35] were omitted because it duplicated that contained in Fan et al. [15]. Data from Toda et al. [37] were omitted because it duplicated information contained in Tang et al. [20]. In the Europe category, only the data regarding Caucasians (Iowa and Australia) in Alward et al. [11] were enumerated, while the reported cases with pigmentary, developmental, and exfoliative data were omitted.
Fisher's
OAG Controls Percent 95% CI bounds exact
------------- ------------- --------------- Odds --------------- test
Source R545Q Total R545Q Total OAG Controls ratio Lower Upper p value
------------ ----- ----- ----- ----- ---- -------- ------ ----- ------- --------
China
[14] 5 118 5 150 4.2 3.3 1.28 0.36 4.54 0.753
[15] 27 400 19 262 6.8 7.3 0.92 0.50 1.70 0.876
Japan
[11] 12 247 3 89 4.9 3.4 1.46 0.40 5.31 0.767
[16] 26 411 11 218 6.3 5.0 1.27 0.62 2.62 0.596
[17] 1 154 0 100 0.6 0.0 1.96* 0.08* 48.69* 1.000
[20] 20 313 10 196 6.4 5.1 1.27 0.58 2.77 0.700
[21] 3 83 4 58 3.6 6.9 0.51 0.11 2.35 0.446
Asia
[This study] 2 6 11 117 33.3 9.4 4.82 0.79 29.36 0.122
Europe
[This study] 0 217 - - 0.0 - - - - -
[11] 0 650 0 162 0.0 0.0 - - - -
[13] 0 27 0 94 0.0 0.0 - - - -
[9] 1 46 0 100 2.2 0.0 6.63* 0.26* 165.80* 0.315
[22] 0 112 - - 0.0 - - - - -
Africa
[This study] 0 81 0 90 0.0 0.0 - - - -
India
[19] 6 200 0 200 3.0 0.0 13.40* 0.75* 239.49* 0.030
Mixed
[23] 0 86 0 80 0.0 0.0 - - - -
[24] 1 114 3 187 0.9 1.6 0.54 0.06 5.28 1.000
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