Table 10 of Ayala-Lugo, Mol Vis 2007; 13:151-163.


Table 10. M98K population data sources and screening methods ordered by ancestry

The following methodologies were used to screen samples for variants. We omitted two studies: Wang et al. [40], a Filipino population, and Forsman et al. [34], a population from south Finland, because they are small family-based studies without population data. SSCP: single-strand conformation polymorphism. DHPLC: denaturing high-performance liquid chromatography. HTCSGE: High throughput conformation sensitive gel electrophoresis. RFLP: Restriction Fragment Length Polymorphisms.

                   Recruitment
                    locations
   Source          (population)          Methodology                   Notes
------------   --------------------   ------------------   ------------------------------
   China

[14]           China-Beijing          SSCP->sequencing
[15]           China-Hong Kong        PCR and
                                      HTCSGE->sequencing
   Japan

[11]           Japan-Gifu             SSCP->sequencing
[16]           Japan-Tokyo,           PCR-RFLP
               Kumamoto, Hamamatsu,
               Hiroshima, Niigata
[17]           Japan-Miyagi           PCR->sequencing
[20]           Japan-Yamanashi        SSCP->sequencing
[21]           Japan-Okayama City     sequencing

   Asia (other than China and Japan)

[This study]   USA-Michigan           PCR->sequencing
               (Korean, Chinese,
               Filipino)
   Europe

[This study]   USA-Michigan           PCR->sequencing      Caucasian
[11]           Australia-Melbourne,   SSCP->sequencing     Australian samples
               Adelaide, USA-Iowa                          areCaucasian (D. Mackey,
                                                           personal report), Iowa
                                                           population >91% Caucasian
                                                           according to the State Data
                                                           Center of Iowa
[12]           England-London         PCR-RFLP             Caucasian
[13]           Australia-New South    PCR-RFLP             mostly Caucasian
               Wales
[32]           Sweden-Uppsala and     DHPLC, PCR,
               Tierps                 SNaPshot
[18]           France-Paris           PCR-RFLP             French and Moroccan Caucasians
[33]           Russia-St.             SSCP, PCR
               Petersburg
[9]            USA-Chicago,           PCR->sequencing      Unspecified cases with
               Connecticut, New       and                  Caucasian controls
               Haven,UK-London,       SSCP->sequencing
               Canada-Toronto
[22]           Germany-Tuebingen,     PCR-RFLP, DHPLC
               Wuerzburg
   Hispanic

[This study]   USA-Michigan,          PCR->sequencing
               Florida, Mexico,
               Panama, Peru, Chile,
               Paraguay
   Africa

[This study]   USA-Michigan, Ghana-   PCR->sequencing      African American and African
               Accra, Sunyani
   India

[19]           India-Hyperabad,       SSCP->sequencing,
               Kolkata                DHPLC, PCR--RFLP
[39]           India-Chennai          PCR->sequencing,
                                      RFLP
   Mixed

[38]           Australia/Tasmania     PCR-RFLP
[36]           USA-New England area   PCR->sequencing,     about 90% Caucasian
                                      DHPLC
[23]           USA-Massachusetts,     PCR->sequencing      about 90% Caucasian
               North Carolina
[24]           Canada-Toronto         PCR-RFLP

Ayala-Lugo, Mol Vis 2007; 13:151-163 <http://www.molvis.org/molvis/v13/a18/>
©2007 Molecular Vision <http://www.molvis.org/molvis/>
ISSN 1090-0535