Table 10 of
Ayala-Lugo, Mol Vis 2007;
13:151-163.
Table 10. M98K population data sources and screening methods ordered by ancestry
The following methodologies were used to screen samples for variants. We omitted two studies: Wang et al. [40], a Filipino population, and Forsman et al. [34], a population from south Finland, because they are small family-based studies without population data. SSCP: single-strand conformation polymorphism. DHPLC: denaturing high-performance liquid chromatography. HTCSGE: High throughput conformation sensitive gel electrophoresis. RFLP: Restriction Fragment Length Polymorphisms.
Recruitment locations Source (population) Methodology Notes ------------ -------------------- ------------------ ------------------------------ China [14] China-Beijing SSCP->sequencing [15] China-Hong Kong PCR and HTCSGE->sequencing Japan [11] Japan-Gifu SSCP->sequencing [16] Japan-Tokyo, PCR-RFLP Kumamoto, Hamamatsu, Hiroshima, Niigata [17] Japan-Miyagi PCR->sequencing [20] Japan-Yamanashi SSCP->sequencing [21] Japan-Okayama City sequencing Asia (other than China and Japan) [This study] USA-Michigan PCR->sequencing (Korean, Chinese, Filipino) Europe [This study] USA-Michigan PCR->sequencing Caucasian [11] Australia-Melbourne, SSCP->sequencing Australian samples Adelaide, USA-Iowa areCaucasian (D. Mackey, personal report), Iowa population >91% Caucasian according to the State Data Center of Iowa [12] England-London PCR-RFLP Caucasian [13] Australia-New South PCR-RFLP mostly Caucasian Wales [32] Sweden-Uppsala and DHPLC, PCR, Tierps SNaPshot [18] France-Paris PCR-RFLP French and Moroccan Caucasians [33] Russia-St. SSCP, PCR Petersburg [9] USA-Chicago, PCR->sequencing Unspecified cases with Connecticut, New and Caucasian controls Haven,UK-London, SSCP->sequencing Canada-Toronto [22] Germany-Tuebingen, PCR-RFLP, DHPLC Wuerzburg Hispanic [This study] USA-Michigan, PCR->sequencing Florida, Mexico, Panama, Peru, Chile, Paraguay Africa [This study] USA-Michigan, Ghana- PCR->sequencing African American and African Accra, Sunyani India [19] India-Hyperabad, SSCP->sequencing, Kolkata DHPLC, PCR--RFLP [39] India-Chennai PCR->sequencing, RFLP Mixed [38] Australia/Tasmania PCR-RFLP [36] USA-New England area PCR->sequencing, about 90% Caucasian DHPLC [23] USA-Massachusetts, PCR->sequencing about 90% Caucasian North Carolina [24] Canada-Toronto PCR-RFLP |