Table 4 of
Soest, Mol Vis 2007;
13:1608-1617.Table 4 of
Soest, Mol Vis 2007;
13:1608-1617.
Table 4. Functional annotation
List of extracellular matrix genes found to be significantly overrepresented among the retinal pigment epithelium genes significant differentially expressed between macula (M) and peripheral parts (P1 and P2) of the human eye. Negative numbers indicate that expression is higher in the paramacular area (P1) or the mid-postequatorial periphery (P2) compared to the macula. M/P1 and M/P2 denotes gene expression fold change observed between, respectively macula and P1, P2.
Genbank
Gene name acc no Description M/ P1 M/ P2
--------- --------- ------------------------------------------------ ----- -----
COL1A1 NM_000088 Collagen, type I, alpha 1 -2 -3.4
COL1A2 NM_000089 Collagen, type I, alpha 2 -1.7 -3.3
COL2A1 NM_001844 Collagen, type II, alpha 1 -8.2 -3.3
COL6A1 NM_001848 Collagen, type VI, alpha 1 -1.2 -1.5
COL6A2 NM_001849 Collagen, type VI, alpha 2 -1.6 -1.5
COL9A2 NM_001852 Collagen, type IX, alpha 2 -1.6 -1.4
COL9A3 NM_001853 Collagen, type IX, alpha 3 -1.4 -1.5
COL12A1 AK022029 Collagen, type XII, alpha 1 -1.8 -1.7
LAMA2 NM_000426 Laminin, alpha 2 -1.4 -1.9
LAMB1 NM_002291 Laminin, beta 1 -1.8 -3
LAMC1 NM_002293 Laminin, gamma 1 (formerly LAMB2) -1.4 -3
COL18A1 NM_030582 Collagen, type XVIII, alpha 1 -1.8 -2
EMILIN1 NM_007046 Elastin microfibril interfacer 1 -1.7 -2.3
FBN1 NM_000138 Fibrillin 1 (Marfan syndrome) -1.6 -2.1
LTBP2 NM_000428 Latent transforming growth factor beta binding -2.7 -4.3
protein 2
MFAP4 L38486 Microfibrillar-associated protein 4 -2.2 -8.8
COMP NM_000095 Cartilage oligomeric matrix protein 1.7 1.6
THBS4 NM_003248 Thrombospondin 4 1.9 1.8
ADAMTS1 NM_006988 ADAM metallopeptidase with thrombospondin type 1 -1.5 -3.6
motif, 1
ADAMTS4 NM_005099 ADAM metallopeptidase with thrombospondin type 1 -1.5 -2.9
motif, 4
GPC3 NM_004484 Glypican 3 -1.8 -3.7
TFPI2 NM_006528 Tissue factor pathway inhibitor 2 -2.7 -3.4
TIMP2 AL110197 TIMP metallopeptidase inhibitor 2 -1.2 -2.9
SPARC NM_003118 Secreted protein, acidic, cysteine-rich 1.4 -2
(osteonectin)
SMOC2 AJ420521 SPARC related modular calcium binding 2 -1.5 -3.4
SPOCK3 NM_016950 Sparc/osteonectin, cwcv and kazal-like domains -1.7 -1.2
proteoglycan (testican) 3
CD248 NM_020404 CD248 molecule, endosialin -1.7 -1.7
FLRT2 NM_013231 Fibronectin leucine rich transmembrane protein 2 1.4 -1.8
KAL1 NM_000216 Kallmann syndrome 1 sequence -1.8 -1.5
NTNG1 AV722613 Netrin G1 -1.1 1.4
RELN NM_005045 Reelin -4.3 -3.6
SGCE NM_003919 Sarcoglycan, epsilon 1.5 -1.7
SOD3 NM_003102 Superoxide dismutase 3, extracellular -3.3 -3.3
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