Figure 6. Effect of age on tau expression in mouse lens

Microtubule-associated proteins were isolated from cortical fiber cells of 1- to 12-month-old mice. Lenses (16-20) from each of wild type (WT), αA^-/--, αB^-/--, and αA/B^-/-- mice were pooled at every age. Proteins were analyzed by immunoblotting with KAM-305 antibody to full length brain tau, and quantified by densitometric analysis. WT (black bars); αA^-/-- (red bars); αB^-/-- (blue bars); αA/B^-/--, (green bars).