Figure 1. Quantitation of blood vessel profiles in the inner retina from mice with oxygen induced retinopathy and treated with mouse GHR ASO ATL 227446 using an early or late intervention protocol

ATL 227446 was associated with a reduction in pathological angiogenesis in mice with oxygen induced retinopathy that was most effective when administered by early intervention. ATL 227446 had no effect on normal physiological angiogenesis in retina of sham mice. The following abbreviations are used: early intervention (EI); late intervention (LI); oxygen induced retinopathy (OIR); growth hormone receptor (GHR) and antisense oligonucleotide (ASO). EI represents treatment between postnatal days 7 and 17. Late intervention represents treatment between postnatal days 12 and 16. Values are mean±sem. N=9 to 10 mice per group. Asterisk denotes p<0.0001 compared to all OIR groups. Cross denotes p<0.001 compared to OIR+vehicle (EI and LI). Double cross denotes p<0.05 compared to all OIR+ATL 227446 late intervention. Double squiggle denotes p<0.0005 compared to all OIR+ATL 227446 late intervention.