Figure 5 of
Cristofanilli, Mol Vis 2007;
13:1496-1507.
Figure 5. Disruption of microtubules has no effect on distribution of Cav1.3 channels
A: Subcellular localization of Cav1.3 channels in control cells, B in cells preincubated for 30 min with 50 μM colchicines, a microtubule disrupter, or C with 5 μM latA, to disrupt F-actin. Latrunculin A, but not colchicine increased cytoplasmic Cav1.3 labeling, as is evident from intensity profiles obtained along the white lines (insets). D: The bar graph summarizes effects of latA and colchicine on Cav1.3 channel internalization. Each column represents the mean±SE (n=20, 3 independent experiments p<0.005).
