Figure 8. The effect of rAAV-angiostatin gene transfer on retinal phosphorylation of p42/p44 MAP kinases at 1 day after STZ-based induction of diabetes

A: Representative blots show retinal phospho-p42/44 MAP kinase and total p42/44 MAP kinase in normal control eyes and in eyes injected with rAAV-lacZ or rAAV-angiostatin. B: Retinal levels of phosphor-p42/p44 MAP kinase one day after STZ-based induction of diabetes was reduced by rAAV-angiostatin (the asterisk indicates significance using the Wilcoxon signed rank test, n=5, p=0.043).