Figure 3. FITC-BSA fluorescence in normal and streptozotocin (STZ)-induced diabetic rat retina

A: Hematoxylin and eosin staining of control retina. B: FITC-BSA fluorescence is limited to the vasculature in the normal retina and in C is diffusely increased throughout the retinal parenchyma at 5 days after STZ-induced diabetes in eyes receiving rAAV-lacZ injection. Increased fluorescence intensity throughout the retinal parenchyma is still present at 10 (D) and 15 (E) days after STZ-induced diabetes in eyes receiving rAAV-lacZ injection. F: Little fluorescence was present in the retinal parenchyma in eyes receiving rAAV-angiostatin injection at 5 days after induction of diabetes. Retinal parenchyma fluorescence at 10 (G) and 15 (H) days after induction of diabetes in eyes with rAAV-angiostatin injection was decreased as compared with eyes with rAAV-lacZ injection. Original magnification was 200X.