Figure 3. An oculocutaneous albinism-affected pedigree showing a potential digenic mode of inheritance involving SLC45A2

A illustrates the locations of the three microsatellite-markers identified in the SLC45A2 locus for cosegregation studies and the position of the Arg348Cys mutation in SLC45A2. B: Haplotype analysis in a pedigree demonstrates that the two affected sibs share one allele carrying the Arg348Cys mutation in SLC45A2 that has been transmitted from their father whereas they harbor different alleles from their mother.